Brain volumetry in fetuses that deliver very preterm: An MRI pilot study

Autor: Lisa Story, Alice Davidson, Prachi Patkee, Bobbi Fleiss, Vanessa Kyriakopoulou, Kathleen Colford, Srividhya Sankaran, Paul Seed, Alice Jones, Jana Hutter, Andrew Shennan, Mary Rutherford
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: NeuroImage: Clinical, Vol 30, Iss , Pp 102650- (2021)
Druh dokumentu: article
ISSN: 2213-1582
DOI: 10.1016/j.nicl.2021.102650
Popis: Background: Infants born preterm are at increased risk of neurological complications resulting in significant morbidity and mortality. The exact mechanism and the impact of antenatal factors has not been fully elucidated, although antenatal infection/inflammation has been implicated in both the aetiology of preterm birth and subsequent neurological sequelae. It is therefore hypothesized that processes driving preterm birth are affecting brain development in utero. This study aims to compare MRI derived regional brain volumes in fetuses that deliver 37 weeks were included. Median gestation at MRI of the preterm group was 26.8 weeks (range 19.4–31.4) and control group 26.2 weeks (range 21.7–31.9). No difference was found in supra-tentorial brain volume, ventricular volume or cerebellar volume but the eCSF and cerebral cortex volumes were smaller in fetuses that delivered preterm (p
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