| Autor: |
Jing Bai, Chunfu Zhang, Yanchun Liang, Adriano Tavares, Lidong Wang, Xue Gu, Ziyao Meng |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Symmetry, Vol 16, Iss 9, p 1136 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2073-8994 |
| DOI: |
10.3390/sym16091136 |
| Popis: |
The changes in cardiomyocyte action potentials are related to variations in intra- and extracellular ion concentrations. Abnormal ion concentrations can lead to irregular action potentials, subsequently affecting wave propagation in myocardial tissue and potentially resulting in the formation of spiral waves. Therefore, timely monitoring of ion concentration changes is essential. This study presents a novel machine learning classification model that predicts ion concentration changes based on action potential variation data. We conducted simulations using a single-cell model, generating a dataset of 850 action potential variations corresponding to different ion concentration changes. The model demonstrated excellent predictive performance, achieving an accuracy of 0.988 on the test set. Additionally, the causes of spontaneous spiral wave generation in the heart are insufficiently studied. This study presents a new mechanism whereby changes in extracellular potassium ion concentration leads to the spontaneous generation of spiral waves. By constructing composite myocardial tissue containing both myocardial and fibroblast cells, we observed that variations in extracellular potassium ion concentration can either trigger or inhibit cardiomyocyte excitation. We developed three tissue structures, and by appropriately adjusting the extracellular potassium ion concentration, we observed the spontaneous generation of single spiral waves, symmetrical spiral wave pairs, and asymmetrical double spiral waves. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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