Comprehensive Analysis of the Expression and Prognosis for in Breast Carcinoma
| Autor: | Zeng-Hong Wu, You-jing Zhang, Jian-Xin Yue, Tao Zhou |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Cell Transplantation, Vol 29 (2020) |
| Druh dokumentu: | article |
| ISSN: | 1555-3892 09636897 |
| DOI: | 10.1177/0963689720962479 |
| Popis: | Secreted frizzled-related proteins ( SFRPs ) are a group of five secreted glycoproteins— SFRP1 , SFRP2 , SFRP3 (frizzled related protein , FRZB ), SFRP4 , and SFRP5 —which contain a frizzled-related cysteine-rich domain and a netrin module. We analyzed SFRPs ’ expression levels, mutations, regulation, functional networks, and correlation with immune infiltration in breast cancer (BC) patients using data from multiple open databases. SFRP1/3/4/5 were downregulated and SFRP2 was upregulated in BC patients compared to healthy controls. Furthermore, higher levels of SFRP1/3/4 were significantly associated with favorable prognosis. In addition, the prognostic significance of the infiltrating B cells was correlated to the SFRPs . Based on these findings, we hypothesize that SFRPs play a synergistic role in BC progression, and are, therefore, promising prognostic biomarkers as well as therapeutic targets. |
| Databáze: | Directory of Open Access Journals |
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