| Autor: |
Ngoc Hoa Nguyen, Christophe Len, Anne-Sophie Castanet, Jacques Mortier |
| Jazyk: |
angličtina |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
Beilstein Journal of Organic Chemistry, Vol 7, Iss 1, Pp 1228-1233 (2011) |
| Druh dokumentu: |
article |
| ISSN: |
1860-5397 |
| DOI: |
10.3762/bjoc.7.143 |
| Popis: |
A regioselective synthesis of 6-ω-alkenyluridines 3, precursors of potent antiviral and antitumor cyclonucleosides 5, is described. While ω-alkenyl halides do not alkylate 6-lithiouridine, compounds 3 were prepared in a regioselective manner by sequential treatment of 6-methyluridine 2 with LTMP or LDA (4 equiv) in THF at −30 °C followed by alkylation with ω-alkenyl bromides. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
