| Autor: |
Linda Ines Zoungrana, Meredith Krause-Hauch, Hao Wang, Mohammad Kasim Fatmi, Zehui Li, Lily Slotabec, Adewale Segun James, Steven Didik, Ji Li |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Biochemistry and Biophysics Reports, Vol 35, Iss , Pp 101550- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2405-5808 |
| DOI: |
10.1016/j.bbrep.2023.101550 |
| Popis: |
Epilepsy is one of the most common and oldest neurological disorders, characterized by periodic seizures that affect millions globally. Despite its long history, its pathophysiology is not fully understood. Additionally, the current treatment methods have their limitations. Finding a new alternative is necessary. Activated Protein C (APC) has been proven to have neurological protection in other neurological disorders; however, there is no study that focuses on the role of APC in seizures. We propose that APC's protective effect could be associated with seizures through inflammation and apoptosis regulation. The results demonstrated that APC's pathway proteins are involved in neuroprotection mechanisms in seizure-induced models by acting on certain inflammatory factors, such as NF-κB and apoptosis proteins. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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