Clinical prediction rules for childhood urinary tract infections: a cross-sectional study in ambulatory care

Autor: Hanne Ann Boon, Jan Y Verbakel, Tine De Burghgraeve, Ann Van den Bruel
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: BJGP Open, Vol 6, Iss 2 (2022)
Druh dokumentu: article
ISSN: 2398-3795
DOI: 10.3399/BJGPO.2021.0171
Popis: Background: Diagnosing childhood urinary tract infections (UTIs) is challenging. Clinical prediction rules may help to identify children that require urine sampling. However, there is a lack of research to determine the accuracy of the scores in general practice. Aim: To validate clinical prediction rules (UTI Calculator [UTICalc], A Diagnosis of Urinary Tract Infection in Young Children [DUTY], and Gorelick score) for paediatric UTIs in primary care. Design & setting: Post-hoc analysis of a cross-sectional study in 39 general practices and two emergency departments (EDs). The study took place in Belgium from March 2019–March 2020. Method: Physicians recruited acutely ill children aged ≤18 years and sampled urine systematically for culture. Per rule, an apparent validation was performed, and sensitivities and specificities were calculated with 95% confidence intervals (CIs) per threshold in the target group. For the DUTY coefficient-based algorithm, a logistic calibration was performed and the area under the receiver operating characteristic curve (AUC) was calculated with 95% CI. Results: Of 834 children aged ≤18 years recruited, there were 297 children aged
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