scMoMaT jointly performs single cell mosaic integration and multi-modal bio-marker detection

Autor: Ziqi Zhang, Haoran Sun, Ragunathan Mariappan, Xi Chen, Xinyu Chen, Mika S. Jain, Mirjana Efremova, Sarah A. Teichmann, Vaibhav Rajan, Xiuwei Zhang
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-023-36066-2
Popis: Many methods for single cell data integration have been developed, though mosaic integration remains challenging. Here the authors present scMoMaT, a mosaic integration method for single cell multi-modality data from multiple batches, that jointly learns cell representations and marker features across modalities for different cell clusters, to interpret the cell clusters from different modalities.
Databáze: Directory of Open Access Journals