| Autor: |
Wern Hann Ng, Patrick Chun Hean Tang, Suresh Mahalingam |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
npj Viruses, Vol 2, Iss 1, Pp 1-3 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2948-1767 |
| DOI: |
10.1038/s44298-024-00064-y |
| Popis: |
Rheumatic symptoms such as joint inflammation and pain are known features of SARS-CoV-2 infection, though the mechanisms remain unclear. Au and colleagues identified the interaction between the viral spike protein and the endothelin-1 (ET-1) signaling pathway as a cause of osteochondral damage. Their study showed that macitentan, an FDA-approved ET-1 receptor antagonist, reduced joint damage and inflammation in a hamster model, suggesting ET-1 as a potential therapeutic target for viral-induced osteoarthritis (OA). |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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