| Autor: |
Sintayehu Asnakew, Getasew Legas, Amare Kassaw, Tigabu Munye Aytenew, Solomon Demis Kebede, Worku Necho Asferie, Netsanet Ejigu, Binyam Minuye Birhane, Yenework Mulu Tiruneh, Birhanu Mengist Munie, Bekalu Mekonnen Belay, Mengistu Ewunetu, Demewoz Kefale |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
BMJ Open, Vol 14, Iss 11 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2044-6055 |
| DOI: |
10.1136/bmjopen-2024-087569 |
| Popis: |
Objective This study aimed to pool the prevalence of virological failure and associated factors.Design Systematic review and meta-analysis.Primary outcome measure Prevalence of virological failure.Secondary outcome measure Factors affecting virological failure.Analysis The extracted data were exported to STATA V.17 for statistical analysis. A random-effects DerSimonian-Laird model was used to compute the pooled prevalence of virological failure.Setting Ethiopia.Participants Patients receiving anti-retroviral therapy.Results A total of 51 primary studies with a sample size of 38, 789 participants were included in the final meta-analysis. The pooled prevalence of virological failure among patients receiving anti-retroviral therapy (ART) in Ethiopia was 15.95% (95% CI: 12.63, 19.27; I2=97.99%; p1000 copies/mL (AOR=4.63, 95% CI: 2.60, 8.26), opportunistic infections (AOR=3.58, 95% CI: 2.58, 4.96) and TB-HIV coinfection (AOR=3.97, 95% CI: 2.41, 6.54) were significantly associated with virological failure among patients receiving anti-retroviral therapy in Ethiopia.Conclusions The pooled prevalence of virological failure among patients receiving anti-retroviral therapy was high in Ethiopia. Therefore, due attention should be given to patients with these identified factors. Moreover, we recommend researchers to conduct a triangulated study that can address additional factors associated with virological failure.PROSPERO registration number The protocol was registered with the Prospero database (PROSPERO, 2024: CRD42024512411). |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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