| Autor: |
Madeline R. Horan, Deo Kumar Srivastava, Nickhill Bhakta, Matthew J. Ehrhardt, Tara M. Brinkman, Justin N. Baker, Yutaka Yasui, Kevin R. Krull, Kirsten K. Ness, Leslie L. Robison, Melissa M. Hudson, I-Chan Huang |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
EClinicalMedicine, Vol 58, Iss , Pp 101921- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2589-5370 |
| DOI: |
10.1016/j.eclinm.2023.101921 |
| Popis: |
Summary: Background: Childhood cancer survivors are at elevated risk for poor health-related quality-of-life (HRQOL). Identification of potentially modifiable risk factors associated with HRQOL is needed to inform survivorship care. Methods: Participants included 4294 adult childhood cancer survivors from the St. Jude Lifetime Cohort Study who completed a survey and clinical assessment at entry into the survivorship cohort (baseline) and follow-up (median interval: 4.3 years) between 2007 and 2019. The SF-6D compared utility-based HRQOL of survivors to an independent sample from the U.S. Medical Expenditures Panel Survey. Chronic health conditions (CHCs) were graded using modified Common Terminology Criteria for Adverse Events. General linear models examined cross-sectional and temporal associations of HRQOL with CHC burden (total and by organ-system), adjusting for potential risk factors. Findings: Survivors reported poorer HRQOL compared to the general population (effect size [d] = −0.343). In cross-sectional analyses at baseline, significant non-demographic risk factors included higher total CHC burden (driven by more severe cardiovascular [d = −0.119, p = 0.002], endocrine [d = −0.112, p = 0.001], gastrointestinal [d = −0.226, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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