Mucosal responses to infection with Trichinella spiralis in mice

Autor:	Kamal M., Wakelin D., Mahida Y.
Jazyk:	angličtina
Rok vydání:	2001
Předmět:	Trichinella spiral intestine worm expulsio mucosa epithelium inflammation mast cells goblet cells Paneth cells T cells cytokines Infectious and parasitic diseases RC109-216
Zdroj:	Parasite, Vol 8, Pp S110-S113 (2001)
Druh dokumentu:	article
ISSN:	1252-607X 1776-1042
DOI:	10.1051/parasite/200108s2110
Popis:	Infections with T. spiralis in mice elicit strong inflammatory responses. The nature and control of these responses, and their relationship to the process of worm expulsion, have been debated for many years. Many components of inflammation are, like worm expulsion, T cell-dependent, but some are not. The paper describes novel observations on Paneth cell responses to infection in immunologically normal mice and in a variety of T cell-deficient mice. Responses occurred normally in nu/nu and scid/scid mice but not in β/δ knock out mice incapable of generating cells with functional TCR. However all of these mice failed to expel worms in the pattern seen in immunologically normal controls. These data are incorporated into a discussion of the causal relevance of intestinal inflammatory changes to the process of worm expulsion.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/9a1aa5869e794c1d91d2d39fabe10d6e Zobrazit plný text záznamu View record in DOAJ