Accurate Cut-off Point for Free to Total Prostate- Specific Antigen Ratio Used to Improve Differentiation of Prostate Cancer from Benign Prostate Hyperplasia in Iranian Population
| Autor: | Khosro Rahbar, Mohammadtaha Jalali, Nasser Kamalian, Javad Sanadizade, Mohammad Sanadizade, Faranak Kazerouni, Houshang Amirrasouli, Kamran Karimi |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Urology Journal, Vol 7, Iss 2, Pp 99-104 (2010) |
| Druh dokumentu: | article |
| ISSN: | 1735-1308 1735-546X |
| Popis: | Purpose: Our aim was to determine a more predictive cut-off value for free to total prostate-specific antigen ratio (f/tPSA) to better differentiate prostate cancer (PCa) from benign prostate hyperplasia (BPH) in Iranian patients with serum PSA levels between 4 and 20 ng/mL.Materials and Methods: This study was performed on 332 men with serum tPSA level of 4 to 20 ng/mL. All patients underwent transrectal ultrasound guided biopsies. Serum levels of tPSA and fPSA were measured by Roche immunoassay Elecsys 2010. Relationship between f/tPSA and cases of PCawas determined.Results: Prostate cancer detected in 49 (15%) patients. Incidence of PCa for serum tPSA level < 10ng/mL and serum tPSA level of 10.1 to 20 ng/ mL was 17 (6.7%) and 32 (39.5%), respectively. Mean f/tPSA value was significantly lower in PCa patients (0.12 ± 0.01) than in benign histology group (0.16 ± 0.03). Among patients with serum PSA level of 4 to 10 ng/mL (n = 251), mean f/tPSA in benign histology group (n = 234) was 0.16 ± 0.08 and in PCa group (n = 17) was 0.13 ± 0.06 (P < .05). For serum PSA level of 10.1 to 20 ng/mL (n = 81), mean f/tPSA in benign histology group (n = 49) was 0.16 ± 0.08 and in PCa group (n = 32) was 0.12 ± 0.05 (P < .05). The cut-off value of 0.12 produced 76% sensitivity and 71 % specificity, whereas the cut-off value of 0.14 yielded 83.5 % sensitivity and 61% specificity.Conclusion: Determination of f/tPSA ratio improves differentiation of Pca from BPH. We recommend a cut-off value of 0.14 to be applied to Iranian patients. |
| Databáze: | Directory of Open Access Journals |
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