Fresh-Packed RBC Infusion Diminishes Acute AlP Poisoned-Patients' Mortality Rate: A Clinical Trial
| Autor: | Nastaran Rahimi, Behnam Behnoush, Hamed Hosseini, Amir A Fakhrabadi, Nina Javadian, Nasrin Barzegari arzegari Dahaj, Adeleh Maleki, Seyed Morteza Tabatabaei, Ahmad Reza Dehpour |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Acta Medica Iranica, Vol 60, Iss 11 (2023) |
| Druh dokumentu: | article |
| ISSN: | 0044-6025 1735-9694 |
| DOI: | 10.18502/acta.v60i11.11652 |
| Popis: | Accidental or intentional poisoning with Aluminum phosphide (AlP) is associated with severe complications such as metabolic acidosis, cardiac failure, and death. Previous animal experiments demonstrated that fresh-packed RBC is protective in an experimental model of AlP poisoning. The aim of this study was to assess the effect of fresh-packed RBC on survival in patients admitted to a referral hospital due to AlP poisoning in a randomized clinical trial. Eighty-two patients were admitted to Clinical Toxicology Unit at Baharloo Hospital due to acute AlP poisoning after approval by the Iranian Registry of Clinical Trials (registration reference: IRCT20180428039443N1). All patients received standard treatment, and forty-one of them received fresh-packed RBC. There was no significant difference between groups in the underlying characteristics, including vital signs and laboratory investigations. But interestingly, the mortality rate was meaningfully decreased (difference: 31.7%, 95% CI: 0.10-0.52) in patients receiving fresh-packed RBC (10 deaths/31 survived; 24.4% mortality) in comparison to standard treatment patients (23 deaths/18 survived; 56.1% mortality). Furthermore, fresh-packed RBC substantially improved the GCS, systolic/diastolic blood pressure, ST changes, and pH 12- and- 24 hours after admission. This study showed that fresh-packed RBC infusion alongside standard supportive treatment leads to a decrease in mortality rate; also, it provided evidence for a protective role of fresh-packed RBC in the management of patients with acute AlP poisoning. |
| Databáze: | Directory of Open Access Journals |
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