Triple-Negative Breast Cancer: A Review of Current Curative Intent Therapies

Autor:	Isaiah MacDonald, Nancy A. Nixon, Omar F. Khan
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	breast cancer triple negative adjuvant neoadjuvant curative intent chemotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Current Oncology, Vol 29, Iss 7, Pp 4768-4778 (2022)
Druh dokumentu:	article
ISSN:	1718-7729 1198-0052
DOI:	10.3390/curroncol29070378
Popis:	Breast cancer is the most commonly diagnosed malignancy in women, with triple-negative breast cancer (TNBC) accounting for 10–20% of cases. Historically, fewer treatment options have existed for this subtype of breast cancer, with cytotoxic chemotherapy playing a predominant role. This article aims to review the current treatment paradigm for curative-intent TNBC, while also reviewing potential future developments in this landscape. In addition to chemotherapy, recent advances in the understanding of the molecular biology of TNBC have led to promising new studies of targeted and immune checkpoint inhibitor therapies in the curative-intent setting. The appropriate selection of TNBC patient subgroups with a higher likelihood of benefit from treatment is critical to identify the best treatment approach.
Databáze:	Directory of Open Access Journals
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