Application of hiPSC as a Drug Tester Via Mimicking a Personalized Mini Heart

Autor: Li Wei, Shutao Xia, Yifei Li, Yan Qi, Yue Wang, Donghui Zhang, Yimin Hua, Shuhua Luo
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Frontiers in Genetics, Vol 13 (2022)
Druh dokumentu: article
ISSN: 1664-8021
DOI: 10.3389/fgene.2022.891159
Popis: Human induced pluripotent stem cells (hIPSC) have been used to produce almost all types of human cells currently, which makes them into several potential applications with replicated patient-specific genotype. Furthermore, hIPSC derived cardiomyocytes assembled engineering heart tissue can be established to achieve multiple functional evaluations by tissue engineering technology. This short review summarized the current advanced applications based on the hIPSC derived heart tissue in molecular mechanisms elucidating and high throughput drug screening.
Databáze: Directory of Open Access Journals