Severe cutaneous scleromyxedema treated by lenalidomide

Autor:	Théo Brochet, Ali Dadban, Quentin Beauvillain, Clemence Boucher, Fanny Dessirier, Christophe Attencourt, Catherine Lok, Pierre Morel, Aurélie Halle, Guillaume Chaby
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	lenalidomide monoclonal gammopathy mucinosis scleromyxedema Dermatology RL1-803 Diseases of the genitourinary system. Urology RC870-923
Zdroj:	JEADV Clinical Practice, Vol 2, Iss 3, Pp 608-611 (2023)
Druh dokumentu:	article
ISSN:	2768-6566
DOI:	10.1002/jvc2.159
Popis:	Abstract Scleromyxedema is a rare clinical variant of primary cutaneous mucinosis. It is defined by a generalized papular and sclerodermoid eruption associated with monoclonal gammopathy. No specific definitive treatment is known and those tried have inconsistent results. The first‐line treatment is intravenous immunoglobulin infusions with variable response and frequent relapse. We describe, here, a patient with scleromyxedema with lambda monoclonal gammopathy treated effectively with low‐dose lenalidomide and dexamethasone. There was no clinical or biological relapse after 3 years of follow‐up. In our opinion, agents targeting the abnormal plasma cell clone like lenalidomide are the most promising in the treatment of scleromyxedema.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/d99ddc440b7c4775ac0026842f026d81 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.