Trex2 responds to damaged replication forks in diverse ways

Autor: Paul Hasty
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Molecular & Cellular Oncology, Vol 8, Iss 2 (2021)
Druh dokumentu: article
ISSN: 2372-3556
23723556
DOI: 10.1080/23723556.2021.1881394
Popis: Three prime Repair Exonuclease 2 (Trex2) alters replication fork (RF) stability and mutation levels in cells defective for homologous recombination (HR). Trex2 has multiple functions that can either cause or supress RF instability in cells with different HR-defects. Why does Trex2 have such diverse effects on RF maintenance?
Databáze: Directory of Open Access Journals
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