The Correlation of Adiponectin, and Visfatin Serum Levels With Ischemic Heart Disease in Postmenopausal women: A population-Based Study

Autor: Hossein Darabi, zahra Behzadi, Taliaeh Zahedi, Mohammadreza Pourbehi, Samad Akbarzadeh, Afshin Ostovar, Majid Assadi, Haerinejad, Zahra Sanjdideh, Iraj Nabipour
Jazyk: English<br />Persian
Rok vydání: 2017
Předmět:
Zdroj: Iranian South Medical Journal, Vol 19, Iss 6, Pp 1011-1021 (2017)
Druh dokumentu: article
ISSN: 1735-4374
1735-6954
Popis: Background: There is a controversial evidence about adiponectin role in cardiovascular diseases and visfatin role has been suggested in pathogenesis of coronary artery disease. Material and Methods: A total of 378 postmenopausal women were randomly selected from 13 clusters in Bushehr Port. The prevalence of ischemic heart disease was assessed by using the Minnesota Code with a 12-lead resting electrocardiogram (EKG). Serum adiponectin and visfatin levels were measured by using enzyme-linked immunosorbent assay methods Results: A total of 159 patients (41.8 percent) were suffering from ischemic heart disease. There was no significant difference between women with ischemic heart disease and healthy postmenopausal women in adiponectin serum level. However, diabetic women with ischemic heart disease, compared with healthy postmenopausal women had a higher level of visfatin (Geometric Mean: 3.05±1.84 ng/ml versus 2.52±1.90 ng/ml, respectively; p=0.023). Multiple logistic regression analysis indicated that higher serum levels of visfatin were significantly associated with a higher prevalence of ischemic heart disease after adjusting for potential confounders, including classical cardiovascular risk factors and circulating hs-CRP levels [odds ratio=3.26, confidence interval (1.14-9.68), p=0.027]. Conclusion: Adiponectin was not correlated with ischemic heart disease among postmenopausal women. But visfatin serum level correlated with ischemic heart disease in postmenopausal non-diabetic women independently from cardiovascular risk factors.
Databáze: Directory of Open Access Journals
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