Comparison of D‐dimer concentration and thromboelastography for diagnosis of cerebrovascular accidents in dogs: A retrospective study

Autor: Elizabeth DiPaola, Starr Cameron, Helena Rylander, Natalia Zidan, Scott Hetzel
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of Veterinary Internal Medicine, Vol 38, Iss 2, Pp 1083-1091 (2024)
Druh dokumentu: article
ISSN: 1939-1676
0891-6640
DOI: 10.1111/jvim.17000
Popis: Abstract Background Cerebrovascular accidents (CVAs) in dogs are diagnosed using magnetic resonance imaging (MRI). This modality is sometimes unavailable, and CVAs can resemble other lesions on MRI. D‐dimer concentration and thromboelastography (TEG) are utilized in human medicine in addition to diagnostic imaging to support diagnosis of CVAs, but their use in veterinary patients has not been assessed. Objective Assess utility of blood D‐dimer concentration and TEG in supporting the imaging diagnosis of CVAs in dogs. Animals Sixty‐eight client‐owned dogs with neurologic signs that had brain MRI and D‐dimer concentration or TEG performed. Methods Multicenter, retrospective study. The incidence of abnormal D‐dimer concentration or TEG was compared between patients with MRI evidence of CVA and a control population. Analysis methods included Fisher's exact test or Chi‐squared test for association and comparison of independent proportions. Results Neither D‐dimer concentration nor TEG was significantly associated with a CVA (P = .38 and .2, respectively). D‐dimer testing was performed in a low‐risk population and showed low sensitivity (30.8%; 95% confidence interval [CI], 10%‐61%) and high specificity (86.4%; 95% CI, 64%‐96%) for CVA diagnosis. Thromboelastography was performed in a high‐risk population and showed moderate sensitivity (64.3%; 95% CI, 44%‐81%) and specificity (66.7%; 95% CI, 24%‐94%) for CVA diagnosis. Abnormal D‐dimer concentration or TEG were not helpful in differentiating hemorrhagic from ischemic stroke (P = .43 and .41, respectively). Conclusions Although blood D‐dimer concentration or TEG alone are not diagnostic of CVAs in dogs, a positive D‐dimer result supports additional testing for CVA.
Databáze: Directory of Open Access Journals
Externí odkaz: