Skeletal muscle adaptation to indirect electrical stimulation: divergence between microvascular and metabolic adaptations

Autor: Roger W. P. Kissane, David Hauton, Peter G. Tickle, Stuart Egginton
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Experimental Physiology, Vol 108, Iss 6, Pp 891-911 (2023)
Druh dokumentu: article
ISSN: 1469-445X
0958-0670
49979612
DOI: 10.1113/EP091134
Popis: Abstract Exercise involves a complex interaction of factors influencing muscle performance, where variations in recruitment pattern (e.g., endurance vs. resistance training) may differentially modulate the local tissue environment (i.e., oxygenation, blood flow, fuel utilization). These exercise stimuli are potent drivers of vascular and metabolic change. However, their relative contribution to adaptive remodelling of skeletal muscle and subsequent performance is unclear. Using implantable devices, indirect electrical stimulation (ES) of locomotor muscles of rat at different pacing frequencies (4, 10 and 40 Hz) was used to differentially recruit hindlimb blood flow and modulate fuel utilization. After 7 days, ES promoted significant remodelling of microvascular composition, increasing capillary density in the cortex of the tibialis anterior by 73%, 110% and 55% for the 4 Hz, 10 and 40 Hz groups, respectively. Additionally, there was remodelling of the whole muscle metabolome, including significantly elevated amino acid turnover, with muscle kynurenic acid levels doubled by pacing at 10 Hz (P
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