| Autor: |
Fernandez-Fernandez Beatriz, Ortiz Alberto, Gomez-Guerrero Carmen, Barat Antonio, Martín-Cleary Catalina, Egido Jesús |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
BMC Nephrology, Vol 13, Iss 1, p 21 (2012) |
| Druh dokumentu: |
article |
| ISSN: |
1471-2369 |
| DOI: |
10.1186/1471-2369-13-21 |
| Popis: |
Abstract Background Dual renin-angiotensin system blockade with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers has been advocated to minimize proteinuria. However, recent trials have questioned the renal safety of this approach. Our understanding on the molecular effects of dual blockade in humans is incomplete. Case presentation We present a patient with corticoid resistant nephrotic syndrome who developed marked juxtaglomerular apparatus hyperplasia and renin expression in the context of dual angiotensin system blockade. Conclusions Although renin may have profibrotic effects mediated by (pro)renin receptor activation, this report raises questions on the potential consequences of local renin activation on chronic kidney disease in patients with dual angiotensin blockade. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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