DETERMINAÇÃO RÁPIDA E SIMULTÂNEA DE PROPIFENAZONA, PARACETAMOL E CAFEÍNA UTILIZANDO ANÁLISE POR INJEÇÃO EM BATELADA COM DETECÇÃO AMPEROMÉTRICA

Autor: Weberson Pereira Silva, Luiz André Juvêncio Silva, Rodrigo Alejandro Abarza Muñoz, Eduardo Mathias Richter
Jazyk: English<br />Spanish; Castilian<br />Portuguese
Předmět:
Zdroj: Química Nova, Vol 40, Iss 10, Pp 1180-1185
Druh dokumentu: article
ISSN: 1678-7064
0100-4042
DOI: 10.21577/0100-4042.20170131
Popis: A fast and simple procedure for simultaneous determination of propyphenazone (PRO), paracetamol (PAR) and caffeine (CAF) was performed using batch injection analysis with multiple pulse amperometric detection (BIA-MPA). Three potentials pulses were selected for the analysis: +0.90 V/50 ms: only PAR was oxidized; +1.20 V/50 ms: oxidation of PAR and PRO without the interference of CAF; +1.60 V/50 ms: oxidation of the three compounds (PAR, PRO and CAF). The sample aliquot (150 µL) was directly injected onto the boron-doped diamond (BDD) electrode immersed in a BIA cell. The analytical characteristics of the proposed method include high analytical frequency (75 injections per hour), good stability (RSD < 3.9%; n = 10), and low detection limits (0.3, 0.2 and 0.1 mg L−1 for PRO, PAR and CAF, respectively). The proposed method yielded similar results to those obtained by liquid chromatography at a 95% confidence level.
Databáze: Directory of Open Access Journals
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