Compromised T Cell Immunity Links Increased Cutaneous Papillomavirus Activity to Squamous Cell Carcinoma Risk

Autor: Luke H. Johnson, Heehwa G. Son, Dat Thinh Ha, John D. Strickley, Joongho Joh, Shadmehr Demehri
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: JID Innovations, Vol 3, Iss 2, Pp 100163- (2023)
Druh dokumentu: article
ISSN: 2667-0267
DOI: 10.1016/j.xjidi.2022.100163
Popis: Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer, with increased incidence in immunosuppressed patients. β-Human papillomavirus has been proposed as a contributor to cSCC risk partly on the basis of increased β-human papillomavirus viral load and seropositivity observed among patients with cSCC. Experimental data in mice colonized with mouse papillomavirus type 1 suggest that T cell immunity against β-human papillomavirus suppresses skin cancer in immunocompetent hosts, and the loss of this immunity leads to the increased risk of cSCC. In this study, we show that CD8+ T cell depletion in mouse papillomavirus type 1‒colonized mice that underwent skin carcinogenesis protocol led to increased viral load in the skin and seropositivity for anti‒mouse papillomavirus type 1 antibodies. These findings provide evidence that compromised T cell immunity can be the link that connects increased β-human papillomavirus detection to cSCC risk.
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