Iranian neonatal diabetes mellitus due to mutation in PDX1 gene: a case report

Autor: Leyla Sahebi, Nikoo Niknafs, Hosein Dalili, Elahe Amini, Tahereh Esmaeilnia, Mahsa Amoli, Nahid Farrokhzad
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Journal of Medical Case Reports, Vol 13, Iss 1, Pp 1-6 (2019)
Druh dokumentu: article
ISSN: 1752-1947
DOI: 10.1186/s13256-019-2149-x
Popis: Abstract Background Neonatal diabetes mellitus with hyperglycemia during the first 6 months of life is a rare disorder that can occur in all races and societies. Case presentation In this study, we introduced an Iranian (Persian) 65-day-old patient with neonatal diabetes mellitus with novel homozygous mutation in the pancreatic and duodenal homeobox 1, PDX1, gene, which is also known as IPF1 gene, located in exon 2. This case was a newborn boy born in Vali-Asr Hospital, Tehran; he was diagnosed as having hyperglycemia on 28th day. Genetic analysis detected a homozygous mutation on PDX1 gene on chromosome 13. It is a novel homozygous mutation in the PDX1 gene (NM_000209.3), p.Phe167Val. This mutation was confirmed by Sanger sequencing. There was no evidence of agenesis of the pancreas. Conclusions We reported a case of neonatal diabetes mellitus due to novel homozygous mutation in the PDX1 gene without exocrine pancreas manifestations.
Databáze: Directory of Open Access Journals
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