Cutibacterium acnes phylogenetic type IC and II isolated from patients with non-acne diseases exhibit high-level biofilm formation

Autor: Keisuke Nakase, Juri Koizumi, Ren Midorikawa, Kento Yamasaki, Miho Tsutsui, Sae Aoki, Yutaka Nasu, Yuji Hirai, Hidemasa Nakaminami, Norihisa Noguchi
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: International Journal of Medical Microbiology, Vol 311, Iss 7, Pp 151538- (2021)
Druh dokumentu: article
ISSN: 1438-4221
DOI: 10.1016/j.ijmm.2021.151538
Popis: Cutibacterium (formerly Propionibacterium) acnes is an important for not only exacerbating factor of acne vulgaris but also pathogen of surgical site infections (SSIs) in orthopedics and plastic surgery. Although biofilm-forming (BF) C. acnes are associated with intractable SSI, characteristics of these strains were still unknown. Here, we explored detailed molecular epidemiological features of BF C. acnes isolated as causative pathogen of infectious diseases. Phylogenetic types of 205 C. acnes strains isolated between 2013 and 2018 from 18 clinical departments of a university hospital in Japan were determined by single-locus sequence type (SLST). Clade H (traditional type IC) and K (type II) which are less relevant with healthy skin and acne vulgaris, were detected in 26.8% (55/205) and 16.1% (33/205) of the strains, respectively. The incidence of them was significantly higher than that of acne patients (H and K, each 2.9%, P
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