Chiral Dualism as an Instrument of Hierarchical Structure Formation in Molecular Biology

Autor:	Vsevolod A. Tverdislov, Ekaterina V. Malyshko
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	chirality proteins nucleic acids hierarchy of structures folding molecular machines Mathematics QA1-939
Zdroj:	Symmetry, Vol 12, Iss 4, p 587 (2020)
Druh dokumentu:	article
ISSN:	2073-8994
DOI:	10.3390/sym12040587
Popis:	The origin of chiral asymmetry in biology has attracted the attention of the research community throughout the years. In this paper we discuss the role of chirality and chirality sign alternation (L–D–L–D in proteins and D–L–D–L in DNA) in promoting self-organization in biology, starting at the level of single molecules and continuing to the level of supramolecular assemblies. In addition, we also discuss chiral assemblies in solutions of homochiral organic molecules. Sign-alternating chiral hierarchies created by proteins and nucleic acids are suggested to create the structural basis for the existence of selected mechanical degrees of freedom required for conformational dynamics in enzymes and macromolecular machines.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/9935c765df9f48c5b9c6e670ebeea7ae Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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