Immune checkpoint inhibitor-associated sarcoidosis reaction

Autor:	Parisa Keshtgar, Parisa Kaviani, Payam Peymani, Neda Kianpour, Samin Karamian
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	immune checkpoint inhibitors renal sarcoidosis-like reaction sarcoidosis immune-related adverse events immune checkpoint inhibitor-associated sarcoidosis granulomas Pathology RB1-214 Internal medicine RC31-1245 Other systems of medicine RZ201-999
Zdroj:	Journal of Nephropathology, Vol 12, Iss 4, Pp e21520-e21520 (2023)
Druh dokumentu:	article
ISSN:	2251-8363 2251-8819
DOI:	10.34172/jnp.2023.21520
Popis:	Immune checkpoint inhibitors (ICIs) constitute a class of drugs that stimulate the immune system to fight cancer cells. However, they can also induce immune-related adverse events (irAEs) in various organs, including the kidneys. One of the infrequent irAEs associated with ICIs is sarcoidosis, an inflammatory disease that can impact multiple organs, such as the lungs, skin, and lymph nodes. Sarcoidosis is characterized by the formation of granulomas, clusters of immune cells that can potentially harm tissues. In some cases, ICIs can trigger kidney sarcoidosis, leading to impaired renal function. The mechanism through which ICIs initiate sarcoidosis is believed to involve activating T cells and cytokines that foster inflammation.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/993471e0f25043699571e0cb3d982397 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF