| Autor: |
Xiang Ma, Jing Wang, Yuhua Shi, Jichun Tan, Yichun Guan, Yun Sun, Bo Zhang, Junli Zhao, Jianqiao Liu, Yunxia Cao, Hong Li, Cuilian Zhang, Feng Chen, Honggang Yi, Ze Wang, Xing Xin, Pingping Kong, Yao Lu, Ling Huang, Yingying Yuan, Haiying Liu, Caihua Li, Ben Willem J. Mol, Zhibin Hu, Heping Zhang, Zi-Jiang Chen, Jiayin Liu |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-024-52008-y |
| Popis: |
Abstract In this multicenter, non-inferiority, randomized trial, we randomly assigned 992 women undergoing in-vitro fertilization (IVF) with a good prognosis (aged 20-40, ≥3 transferrable cleavage-stage embryos) to strategies of blastocyst-stage (n = 497) or cleavage-stage (n = 495) single embryo transfer. Primary outcome was cumulative live-birth rate after up to three transfers. Secondary outcomes were cumulative live-births after all embryo transfers within 1 year of randomization, pregnancy outcomes, obstetric-perinatal complications, and livebirths outcomes. Live-birth rates were 74.8% in blastocyst-stage group versus 66.3% in cleavage-stage group (relative risk 1.13, 95%CI:1.04-1.22; Pnon-inferiority 3 days. Among good prognosis women, a strategy of single blastocyst transfer increases cumulative live-birth rates over single cleavage-stage transfer. Blastocyst transfer resulted in higher preterm birth rates. This information should be used to counsel patients on their choice between cleavage-stage and blastocyst-stage transfer (NCT03152643, https://clinicaltrials.gov/study/NCT03152643 ). |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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