| Autor: |
Eyiuche Doris Ezigbo, Obioma Edeh, Chidinma I. Onwuka, Helen Choma Okoye, Chibueze D. Onah, Favour C. Agbo |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Advances in Biomedical and Health Sciences, Vol 3, Iss 3, Pp 143-151 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2773-1553 |
| DOI: |
10.4103/abhs.abhs_21_24 |
| Popis: |
Background: Menorrhagia affects 18 million women globally aged 30–55 years and poses a significant health concern. This study assessed the coagulation profile of pregnant women with bleeding problems who were screened for von Willebrand Disease (VWD). Methods: This cross-sectional study included 150 pregnant women from the Odumegwu Ojukwu University and Enugu State University Teaching Hospitals. Forty-five age-matched nonpregnant women served as controls. Blood samples were collected for coagulation studies, complete blood counts, and measurement of von Willebrand factor parameters. Data were collected from January 2021 to August 2022, and bleeding severity was assessed using the International Society for Thrombosis and Haemostasis-Bleeding Assessment Tool. Categorical variables are represented as frequencies and percentages. The Kruskal–Wallis test and descriptive statistics were performed for continuous variables. Dunn’s multiple comparison test was performed for the groups, whereas the Mann–Whitney U test was used for the two groups. Statistical significance was set at P < 0.05. Results: Postpartum hemorrhage (38%) was the most prevalent symptom. Levels of VWF: Ag, FVIII, and VWF:CB increased as pregnancy progressed but were significantly lower in pregnant women with a history of bleeding. A low FVIII:C/VWF:Ag ratio ( |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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