Determinação de fármacos diuréticos em associação por cromatografia em camada delgada e espectrofotometria Determination of diuretic drugs by thin layer chromatography and spectrophotometry
| Autor: | Dênia Mendes de Sousa Valladão, Massao Ionashiro, José Zuanon Netto |
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| Jazyk: | English<br />Spanish; Castilian<br />Portuguese |
| Rok vydání: | 2008 |
| Předmět: | |
| Zdroj: | Química Nova, Vol 31, Iss 1, Pp 44-46 (2008) |
| Druh dokumentu: | article |
| ISSN: | 0100-4042 1678-7064 |
| DOI: | 10.1590/S0100-40422008000100009 |
| Popis: | A rapid, sensitive and reliable thin-layer chromatography/spectrophotometry screening procedure was developed for quantitative determination of diuretics associated in pharmaceutical dosage forms. The chromatographic method employed microcrystalline cellulose and butanol : acetic acid : water (4:1:1) or amilic alcohol : ammonium hydroxide 25% (9:1) as mobile phases and detection by U.V. light. The drugs were extracted using a simple procedure and were quantified by U.V. spectrophotometry. Results varied from 97.5 to 102.5% and are similar to those obtained by conventional methods. This method of quantification of diuretics is promising for quality control of drugs. |
| Databáze: | Directory of Open Access Journals |
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