Methotrexate-induced changes in the concentration of antibodies to modified citrulnated vimentin in blood serum of patients with rheumatoid arthritis
| Autor: | Natal'ya Petrovna Shilkina, Mariya Sergeevna Voronina, Aleksey Alekseevich Vinogradov, Ol'ga L'vovna Borisova, N P Shilkina, M S Voronina, A A Vinogradov, O L Borisova |
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| Jazyk: | ruština |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Терапевтический архив, Vol 83, Iss 5, Pp 10-13 (2011) |
| Druh dokumentu: | article |
| ISSN: | 0040-3660 2309-5342 |
| Popis: | Aim. To study effects of methotrexate on the titer of antibodies to mutated citrullinated vimentin (anti-MCV) and ascertain possibility of using this marker for control of treatment results and choice of individual effective dose of the drug. Material and methods. A 12-month trial included 76 patients with verified rheumatoid arthritis (RA). Methotrexate per os was given in a dose 7.5-10 mg/week to 44(57.9%) patients, 25 patients received no basic therapy. Anti-MCV (IU/ml) were detected with commercial chemicals made in Germany (ORGENTEC). Results. RA patients given methotrexate doses 7.5 and 10 mg/week and untreated with basic anti-inflammatory drugs showed no significant differences by basic clinical and device parameters, level of anti-MCV at primary examination and 12 months later. Conclusion. Anti-MCV titer cannot be used for control of efficacy of methotrexate treatment in doses 75 and 10 mg/week, choice of individual effective doses. |
| Databáze: | Directory of Open Access Journals |
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