Mirabegron for medical expulsive therapy of ureteral stones: a systematic review and meta-analysis

Autor: Haifeng Song, Lei Liang, Hui Liu, Yubao Liu, Weiguo Hu, Gang Zhang, Bo Xiao, Meng Fu, Jianxing Li
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Frontiers in Medicine, Vol 10 (2024)
Druh dokumentu: article
ISSN: 2296-858X
DOI: 10.3389/fmed.2023.1280487
Popis: ObjectiveTo systematically review and quantitively evaluate the efficacy and safety of mirabegron as a medical expulsive therapy for ureteral stones.MethodsWe performed an extensive search of the EMBASE and PubMed databases for studies examining the use of mirabegron as a medical expulsive therapy for ureteral stones. The primary outcome measure assessed was the stone expulsion rate (SER), while the secondary outcomes evaluated were the stone expulsion interval (SEI) and the occurrence of pain episodes during follow-up. Risk ratios (RRs) and mean differences (MDs) with their respective 95% CIs were calculated.ResultsWe included a total of seven studies involving 728 participants. Our analysis revealed a significant increase in the stone expulsion rate (SER) with mirabegron (RR = 1.40; 95% CI = 1.17–1.67; p
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