| Autor: |
Shuichi Hara, Masamune Kobayash, Fumi Kuriiwa, Kunihiko Kurosaki, Hajime Mizukami |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Genomics Data, Vol 12, Iss C, Pp 74-75 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
2213-5960 |
| DOI: |
10.1016/j.gdata.2017.03.007 |
| Popis: |
Carbon monoxide (CO) poisoning causes brain damage, which is attenuated by treatment with hydrogen [1,2], a scavenger selective to hydroxyl radical (·≡OH) [3]. This suggests a role of ·≡OH in brain damage due to CO poisoning. Studies have shown strong enhancement of ·≡OH production in rat striatum by severe CO poisoning with a blood carboxyhemoglobin (COHb) level >70% due to 3000 ppm CO, but not less severe CO poisoning with a blood COHb level at approximately 50% due to 1000 ppm CO [4]. Interestingly, 5% O2 causes hypoxia comparable with that by 3000 ppm CO and produces much less •OH than 3000 ppm CO does [4]. In addition, cAMP production in parallel with ·≡OH production [5] might contribute to ·≡OH production [6]. It is likely that mechanisms other than hypoxia contribute to brain damage due to CO poisoning [7]. To search for the mechanisms, we examined the effects of 1000 ppm CO, 3000 ppm CO and 5% O2 on gene expression in rat striatum. All array data have been deposited in the Gene Expression Omnibus (GEO) database under accession number GSE94780. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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