Eight weeks of mineralocorticoid blockade does not improve insulin sensitivity in type 2 diabetes

Autor: Stine H. Finsen, Mie R. Hansen, Joachim Hoffmann‐Petersen, Henrik F. Højgaard, Stefan P. Mortensen
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Physiological Reports, Vol 9, Iss 15, Pp n/a-n/a (2021)
Druh dokumentu: article
ISSN: 2051-817X
DOI: 10.14814/phy2.14971
Popis: Abstract Individuals with type 2 diabetes have an increased risk of cardiovascular disease. A correlation between plasma aldosterone and hyperinsulinemia has been demonstrated in vivo, and hyperinsulinemia and insulin resistance are independently associated with the development of cardiovascular complications. We investigated if mineralocorticoid blockade (Eplerenone) improves insulin sensitivity in individuals with type 2 diabetes compared to healthy controls. We included 13 participants with type 2 diabetes (
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