| Autor: |
LUO Qingyi, ZHANG Tiling, DING Yunchuan, CHEN Jian, ZHAO Li, WANG Qinghui |
| Jazyk: |
čínština |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Shiyan dongwu yu bijiao yixue, Vol 42, Iss 5, Pp 401-408 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1674-5817 |
| DOI: |
10.12300/j.issn.1674-5817.2022.020 |
| Popis: |
ObjectiveTo investigate the method and feasibility of establishing a rabbit heart-failure model using transverse aortic constriction (TAC).MethodsTwenty-five healthy male Japanese white rabbits were randomly divided into an operation group (n=15) and a sham-operation group (n=10). The animals in the operation group underwent TAC to establish the rabbit model of heart failure. The sham-operation group underwent thoracotomy but no narrowing operation. Cardiac function was evaluated using ultrasound at 4 and 8 weeks after operation. Eight weeks after operation, the descending aortic flow velocity was detected using cardiac ultrasound, combined with molecular biological indexes and pathological observations to verify the feasibility and stability of TAC in establishing the rabbit heart-failure model.ResultsEight weeks after operation, 13 rabbits in the operation group and 10 in the sham-operation group survived. The blood flow velocities at the constriction in the operation group were >2.20 m/s. Compared with the sham-operation group, the following outcomes in the operation group increased significantly (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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