| Autor: |
Fabr.ício Tavares Mendon..a, Jorge Humberto Barreto Filho, Matheus de Bastos Cerqueira Soares Hungria, Thiago Cavalcante Magalh.·es |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Brazilian Journal of Anesthesiology, Vol 73, Iss 4, Pp 426-433 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
0104-0014 |
| DOI: |
10.1016/j.bjane.2021.08.012 |
| Popis: |
Background: Few trials have examined the efficacy of esmolol to attenuate hemodynamic and respiratory responses during extubation. However, the most appropriate dose of esmolol and an optimal protocol for administering this beta-blocker are uncertain. Methods: Ninety patients ASA physical status I, II, and III (aged 18...60 years) scheduled to procedures with general anesthesia and tracheal extubation were selected. Patients were randomized into esmolol and placebo group to evaluate the efficacy and safety of a single bolus dose of esmolol (2...mg.kg-1) on cardiorespiratory responses during the peri-extubation period. The primary outcome was the rate of tachycardia during extubation. Results: The rate of tachycardia was significantly lower in esmolol-treated patients compared to placebo-treated patients (2.2% vs. 48.9%, relative risk (RR): 0.04, 95% confidence interval (95% CI)...=...0.01 to 0.32, p...=...0.002). The rate of hypertension was also significantly lower in the esmolol group (4.4% vs. 31.1%, RR: 0.14, 95% CI 0.03 to 0.6, p...=...0.004). Esmolol-treated patients were associated with higher extubation quality compared to patients who received placebo (p... |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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