Ratio of carbon dioxide veno-arterial difference to oxygen arterial-venous difference is not associated with lactate decrease after fluid bolus in critically ill patients with hyperlactatemia: results from a prospective observational study

Autor:	Keitiane Kaefer, Charalampos Pierrakos, Thomas Nguyen, Dimitrios Velissaris, Rachid Attou, Jacques Devriendt, Sabino Scolletta, Fabio Silvio Taccone
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Fluid challenge Fluid expansion Oxygen consumption Tissue hypoxia PCO2 gap Veno-arterial carbon dioxide gap Anesthesiology RD78.3-87.3
Zdroj:	BMC Anesthesiology, Vol 23, Iss 1, Pp 1-9 (2023)
Druh dokumentu:	article
ISSN:	1471-2253
DOI:	10.1186/s12871-023-01993-6
Popis:	Abstract Background High ratio of the carbon dioxide veno-arterial difference to the oxygen arterial-venous difference (PvaCO2/CavO2) is associated with fluid bolus (FB) induced increase in oxygen consumption (VO2). This study investigated whether PvaCO2/CavO2 was associated with decreases in blood-lactate levels FB in critically ill patients with hyperlactatemia. Methods This prospective observational study examined adult patients in the intensive care unit (ICU) with lactate levels > 1.5 mmol/L who received FBs. Blood-lactate levels were measured before and after FB under unchanged metabolic, respiratory, and hemodynamic conditions. The primary outcome was blood-lactate levels after FB. Significant decreases in blood-lactate levels were considered as blood-lactate levels
Databáze:	Directory of Open Access Journals
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