Effects of highly purified sardine proteins on lipid peroxidation and reverse cholesterol transport in rats fed a cholesterol-rich diet

Autor: Sabrine Louala, Sherazed Hamza-Reguig, Aicha Benyahia-Mostefaoui, Ahmed Boualga, Myriem Y. Lamri-Senhadji
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Zdroj: Journal of Functional Foods, Vol 3, Iss 4, Pp 321-328 (2011)
Druh dokumentu: article
ISSN: 1756-4646
DOI: 10.1016/j.jff.2011.07.002
Popis: The effect of highly purified sardine proteins was compared with that of casein on serum and lipoproteins lipid peroxidation and reverse cholesterol transport. Lecithin:cholesterol acyltransferase (LCAT) activity, high density lipoproteins (HDL2 and HDL3) composition and serum lipid and lipoproteins peroxidation were determined in rats fed a cholesterol-rich diet. Hypercholesterolemic rats were divided into two groups fed diets enriched with cholesterol and containing 20% of highly purified sardine proteins (SPc) or casein (CASc) for 28 days. A control group was fed a standard diet (CAS). Compared with CAS and CASc, the thiobarbituric acid reactive substances (TBARS) concentrations of low density lipoprotein (LDL)–HDL1 in SPc were 3.5- and 1.7-fold higher compared with casein diets. TBARS in HDL2 and HDL3 were, respectively, 2.3- and 1.6-fold lower in SPc compared with CASc. In SPc group, LCAT activity was higher compared to CASc and CAS (P
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