The causal relationship between 233 metabolites and coronary atherosclerosis: a Mendelian randomization study

Autor: Hongwei Zhang, Xiaoyu Zheng, Zian Yan, Lijun Guo, Yuan Zheng, Dawu Zhang, Xiaochang Ma
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Frontiers in Cardiovascular Medicine, Vol 11 (2024)
Druh dokumentu: article
ISSN: 2297-055X
DOI: 10.3389/fcvm.2024.1439699
Popis: ObjectiveTo investigate the causal relationship between 233 newly reported metabolites and coronary atherosclerosis through Mendelian randomization analysis.MethodsFive different methods were used to perform Mendelian randomization analysis on the 233 metabolites and coronary atherosclerosis, with inverse variance weighting as the primary result, supplemented by other methods.ResultsThe analysis identified that certain metabolites increase the susceptibility risk of coronary atherosclerosis, including: Total fatty acids (OR = 1.40, 95% CI: 1.28–1.53, P
Databáze: Directory of Open Access Journals