Pseudolaric Acid B Targets CD147 to Selectively Kill Acute Myeloid Leukemia Cells

Autor:	Sheng Zou, Ekaterina Parfenova, Nikolina Vrdoljak, Mark D. Minden, Paul A. Spagnuolo
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	pseudolaric acid B (PAB) CD147 (EMMPRIN/BSG/BASIGIN) acute myeloid leukemia (AML) nuclear factor kB (NF-κB) pathway cell proliferation apoptosis Biology (General) QH301-705.5 Chemistry QD1-999
Zdroj:	International Journal of Molecular Sciences, Vol 25, Iss 12, p 6517 (2024)
Druh dokumentu:	article
ISSN:	1422-0067 1661-6596
DOI:	10.3390/ijms25126517
Popis:	Acute myeloid leukemia (AML) is an aggressive blood cancer. With low survival rates, new drug targets are needed to improve treatment regimens and patient outcomes. Pseudolaric acid B (PAB) is a plant-derived bioactive compound predicted to interact with cluster of differentiation 147 (CD147/BSG). CD147 is a transmembrane glycoprotein overexpressed in various malignancies with suggested roles in regulating cancer cell survival, proliferation, invasion, and apoptosis. However, the detailed function of PAB in AML remains unknown. In this study, AML cell lines and patient-derived cells were used to show that PAB selectively targeted AML (IC50: 1.59 ± 0.47 µM). Moreover, proliferation assays, flow cytometry, and immunoblotting confirmed that PAB targeting of CD147 resulted in AML cell apoptosis. Indeed, the genetic silencing of CD147 significantly suppressed AML cell growth and attenuated PAB activity. Overall, PAB imparts anti-AML activity through transmembrane glycoprotein CD147.
Databáze:	Directory of Open Access Journals
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