Efficiency and Safety of the Domestic Device KERATOLINK for the Treatment of Patients with Bacterial Corneal Ulcers

Autor: K. E. Seliverstova, E. N. Iomdina, E. V. Yani
Jazyk: ruština
Rok vydání: 2024
Předmět:
Zdroj: Oftalʹmologiâ, Vol 21, Iss 3, Pp 502-508 (2024)
Druh dokumentu: article
ISSN: 1816-5095
2500-0845
DOI: 10.18008/1816-5095-2024-3-502-508
Popis: Ultraviolet cross-linking (CXL) of corneal collagen is one of the promising methods for treating bacterial corneal ulcers.Purpose of the work: to evaluate the effectiveness and safety of the use of a new domestic device for corneal CXL KERATOLINK in the treatment of patients with a bacterial corneal ulcer.Materials and methods. Local CXL was performed in 24 patients (24 eyes) aged from 18 to 74 years, who made up the main group. The comparison group included 10 patients of the same age group. To treat ulcerative lesions, drug therapy (antibacterial, corticosteroid, tear replacement and reparative) was used in both groups, but CXL was also used in the main group. The CXL procedure was performed for 5 minutes using the “accelerated cross-linking 2 — ACL 2” program. Each patient underwent 3 procedures with an interval of 2 days. Ophthalmological examination in the main group before treatment, 3 days after the 1st, 2nd and 3rd procedures, as well as 1, 3, 6 months after completion of CXL included visometry, tonometry, microbiological examination of discharge, determination of the size of the defect, optical coherence tomography of the anterior department of the eye (OCT-AS). The comparison group was examined at the same time using the same set of methods.Results. All CXL procedures were completed without complications, no adverse events were identified, and in all cases the recovery period was uneventful. 6 months after CXL, the average uncorrected visual acuity increased from 0.029 ± 0.026 to 0.195 ± 0.175. Already 3 days after the third CXL procedure, there was an absence of microorganisms in the cultures, a significant decrease in the area and depth of the corneal defect (associated with its almost complete epithelization) and a decrease in inflammatory edema according to OCT-АS data. The average period of epithelization of the ulcerative defect was 12 days. Subsequently, stable healing was observed for 6 months, no relapses were detected. In the comparison group, on the 15th day of observation, complete epithelialization was achieved in only 40% of patients.Conclusion. CXL using the KERATOLINK device is a technically simple, minimally invasive method for treating corneal ulcers. A significant reduction in epithelialization time and an increase in visual acuity indicate the effectiveness and safety of the accelerated CXL procedure. The use of an accelerated local CXL protocol with a significant reduction in exposure time helps to increase the comfort and tolerability of the procedure, as well as reduce the risk of complications.
Databáze: Directory of Open Access Journals
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