Evaluation of a long‐acting injectable formulation of omeprazole in healthy dogs

Autor: Adesola Odunayo, Gina Galyon, Joshua Price, Silke Hecht, M. Katherine Tolbert
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Veterinary Internal Medicine, Vol 36, Iss 4, Pp 1416-1421 (2022)
Druh dokumentu: article
ISSN: 1939-1676
0891-6640
DOI: 10.1111/jvim.16440
Popis: Abstract Background To evaluate the efficacy of a single intramuscular adminsitration of long‐acting omeprazole (LA‐OMEP) in increasing gastric pH in dogs. Hypothesis We hypothesized that LA‐OMEP would meet in healthy dogs the clinical goals defined for human patients for treatment of gastroduodenal ulceration. Animals Nine healthy research dogs. Methods Prospective experimental study. Dogs were given a 4 mg/kg intramuscular injection of LA‐OMEP. Intragastric pH was continuously recorded on treatment days 0 to 7. Daily mean pH and mean percentage time (MPT) intragastric pH was ≥3 or ≥4 were determined. Results The mean onset of action for the LA‐OMEP was 98.11 min (SD 46.39). The mean number of days the dogs' pH met established goals for MPT pH ≥3 was 5.5 days (range, 3‐7) and 5.25 days for MPT pH ≥4 (range, 3‐7). Long‐acting omeprazole met the human clinical goals pH ≥3 for 72 hours in 8/8 of the dogs and MPT pH ≥4 for 96 hours in 7/8 of dogs. Conclusions and Clinical Importance The LA‐OMEP formulation produced gastric acid suppression in healthy dogs for an average of 5 days and up to 7 days, after a single intramuscular injection. No major adverse effects were observed.
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