Epidermodisplasia verruciforme: tratamento combinado com acitretina e interferon alfa-2a Epidermodysplasia verruciformis: combined treatment with acitretin and interferon alpha-2a
| Autor: | Cristiana Silveira Silva, Rodrigo de Oliveira Ramos, Mario Cezar Pires, José Alexandre S. Sittart |
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| Jazyk: | English<br />Portuguese |
| Rok vydání: | 2006 |
| Předmět: | |
| Zdroj: | Anais Brasileiros de Dermatologia, Vol 81, Iss 6, Pp 595-597 (2006) |
| Druh dokumentu: | article |
| ISSN: | 0365-0596 1806-4841 |
| DOI: | 10.1590/S0365-05962006000600013 |
| Popis: | Comunica-se o resultado do tratamento com acitretina e interferon alfa-2a em doente de 16 anos de idade com epidermodisplasia verruciforme. O diagnóstico foi realizado mediante os achados clínico-histopatológicos e pesquisa in situ positiva para papiloma vírus humano. O quadro clínico era extenso e resistente a outros tratamentos, com risco de desenvolvimento de neoplasias. Houve melhora clínica 30 dias após o início do tratamento, mantida durante os 16 meses de seguimento.We report the result of a treatment with acitretin and alpha-2a interferon in a 16-year-old boy with epidermodysplasia verruciformis. Diagnosis was based on clinical features, histopathological examination and positivity for in situ HPV. The affection was extensive and resistant to other treatment modalities, with a high risk of development of neoplasias. Treatment with oral acitretin associated with subcutaneous recombinant interferon alpha-2a three times per week induced improvement, which was sustained for 16 months of follow-up. |
| Databáze: | Directory of Open Access Journals |
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