Dysfunction of the glymphatic system in childhood absence epilepsy

Autor: Wanqing Pu, Shanzhen Wei, Mengdi Qiu, Xiaoyu Chen, Wenwei Zou, Yingchao Ge, Wenchao Qiu
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Frontiers in Neuroscience, Vol 17 (2023)
Druh dokumentu: article
ISSN: 1662-453X
DOI: 10.3389/fnins.2023.1312676
Popis: ObjectiveThis study aimed to evaluate the glymphatic system in childhood absence epilepsy (CAE) using diffusion tensor image analysis along the paravascular space (DTI-ALPS) index. Methods: Forty-two CAE patients and 50 age- and gender-matched healthy controls (HC) were included in this study. All participants underwent scanning using a Siemens 3.0 T magnetic resonance scanner, and the DTI-ALPS index was calculated. The study compared the differences of DTI-ALPS index between CAE patients and the healthy controls. Additionally, this study also assessed the relationship between the DTI-ALPS index and clinical characteristics such as age, seizure frequency, and duration of epilepsy.ResultsThe DTI-ALPS index was lower in CAE patients compared to the healthy controls (1.45 ± 0.36 vs. 1.66 ± 0.30, p
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