Effect of Sodium Cromoglycate on Acetic Acid-induced Ulcerative Colitis in Mice
| Autor: | Zahra Ghafouri, Saeid Seyyedian, Jafar Nikbakht, Ebrahim Kouhsari, Sara Bayat, Hamidreza Zargar, Gholamreza Houshmand |
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| Jazyk: | English<br />Korean |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | The Korean Journal of Gastroenterology, Vol 75, Iss 1, Pp 39-45 (2020) |
| Druh dokumentu: | article |
| ISSN: | 1598-9992 2233-6869 |
| DOI: | 10.4166/kjg.2020.75.1.39 |
| Popis: | Background/Aims: Ulcerative colitis (UC) is a type of inflammatory bowel disease that mainly involves the colon. Thus far, glucocorticoids and amino-salicylate have been the main treatment. Methods: To assess drugs with fewer side effects, this study evaluated the effects of sodium cromoglycate (SCG) on acetic acid-induced UC in rats. The treatment groups included SCG receivers (50 and 100 mg/kg, intra-orally) and sulfasalazine (SSZ) receivers (100 mg/kg, intra-orally). The colonic mucosal injury was assessed by clinical, macroscopic, and histopathological examinations. Results: In the treatment groups with 50 and 100 mg/kg of SCG, the clinical activity score decreased to 2.67±0.18 and 1.73±0.21 (p |
| Databáze: | Directory of Open Access Journals |
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