ARGV: 3D genome structure exploration using augmented reality

Autor:	Chrisostomos Drogaris, Yanlin Zhang, Eric Zhang, Elena Nazarova, Roman Sarrazin-Gendron, Sélik Wilhelm-Landry, Yan Cyr, Jacek Majewski, Mathieu Blanchette, Jérôme Waldispühl
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	3D genome browser 3D genome organization Augmented reality AR Virtual reality VR Mobile app Computer applications to medicine. Medical informatics R858-859.7 Biology (General) QH301-705.5
Zdroj:	BMC Bioinformatics, Vol 25, Iss 1, Pp 1-14 (2024)
Druh dokumentu:	article
ISSN:	1471-2105
DOI:	10.1186/s12859-024-05882-8
Popis:	Abstract Over the past two decades, scientists have increasingly realized the importance of the three-dimensional (3D) genome organization in regulating cellular activity. Hi-C and related experiments yield 2D contact matrices that can be used to infer 3D models of chromosome structure. Visualizing and analyzing genomes in 3D space remains challenging. Here, we present ARGV, an augmented reality 3D Genome Viewer. ARGV contains more than 350 pre-computed and annotated genome structures inferred from Hi-C and imaging data. It offers interactive and collaborative visualization of genomes in 3D space, using standard mobile phones or tablets. A user study comparing ARGV to existing tools demonstrates its benefits.
Databáze:	Directory of Open Access Journals
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