| Autor: |
Tayyaba Afzal, Ghazala Kaukab Raja, Maimoona Afzal, Shakeel Ahmad, Nighat Sultana, Umm e Kalsoom |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Journal of the Pakistan Medical Association, Vol 71, Iss 1 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
0030-9982 |
| DOI: |
10.47391/JPMA.1026 |
| Popis: |
Polycystic ovary syndrome (PCOS) is an oligogenic condition, characterised by hyperandrogenism, ovulatory dysfunction and polycystic ovarian morphology. Previously, European and Han Chinese populations identified different susceptibility loci, of which ERBB4 (rs1351592) was strongly associated with PCOS. Our study aimed to investigate the association of ERBB4 Single Nucleotide Polymorphism (SNP), rs1351592 with PCOS in Pakistani women of Hazara region. Fifty PCOS patients and 14 healthy women were recruited and SNP was replicated using ARMS-PCR and sequencing. The study showed that Luteinising Hormone (LH), Follicle Stimulating Hormone (FSH), and Testosterone (T) were significantly elevated in patients compared to controls (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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