Synthesis of purin 2'-deoxynucleoside analogues by using thioglycosides: 2',3'-dideoxyguanosine
| Autor: | G. D. Gungarova, A. I. Davydova, Yu. G. Kirillova, V. I. Shvets |
|---|---|
| Jazyk: | ruština |
| Rok vydání: | 2006 |
| Předmět: | |
| Zdroj: | Тонкие химические технологии, Vol 1, Iss 1, Pp 19-22 (2006) |
| Druh dokumentu: | article |
| ISSN: | 2410-6593 2686-7575 |
| Popis: | Synthesis of purine 2'-deoxynucleoside analogues derivatives, named by using thioglycosides: 2',3'-dideoxyguanosine (3) and 2',3'-dideoxyguanosine (4) is described. This approach is based on condensation of S-glycoside (5) with silylated heterocyclic based (6,7) using N-bromosuccinimide as promoter. It is know that in the process of glycosylation reaction a mixture of three isomers, namely aN9, aN7 and bN7 is formed besides the desired bN9. In order to prevent undered formation of N7 isomers 2-aminogroup of adenine and 6-oxogroupvof guanine were modified by bulky protective gpoups |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|