Role of the microbiome in occurrence, development and treatment of pancreatic cancer

Autor:	Yicheng Wang, Gang Yang, Lei You, Jinshou Yang, Mengyu Feng, Jiangdong Qiu, Fangyu Zhao, Yueze Liu, Zhe Cao, Lianfang Zheng, Taiping Zhang, Yupei Zhao
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Pancreatic cancer Microbiomes Chemotherapy Diagnosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Molecular Cancer, Vol 18, Iss 1, Pp 1-13 (2019)
Druh dokumentu:	article
ISSN:	1476-4598
DOI:	10.1186/s12943-019-1103-2
Popis:	Abstract Pancreatic cancer is one of the most lethal malignancies. Recent studies indicated that development of pancreatic cancer may be intimately connected with the microbiome. In this review, we discuss the mechanisms through which microbiomes affect the development of pancreatic cancer, including inflammation and immunomodulation. Potential therapeutic and diagnostic applications of microbiomes are also discussed. For example, microbiomes may serve as diagnostic markers for pancreatic cancer, and may also play an important role in determining the efficacies of treatments such as chemo- and immunotherapies. Future studies will provide additional insights into the various roles of microbiomes in pancreatic cancer.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/987b565ef19c49dfa435e6b8f69cb87a Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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