Prevalence and clinical forms of celiac disease in siblings of children with verified disease

Autor: Leković Zoran, Radlović Vladimir, Mladenović Marija, Dučić Siniša, Đuričić Goran, Predojević-Samardžić Jelica, Vuletić Biljana, Rosić Petar, Janković Srđa, Radlović Nedeljko
Jazyk: English<br />Serbian
Rok vydání: 2023
Předmět:
Zdroj: Srpski Arhiv za Celokupno Lekarstvo, Vol 151, Iss 7-8, Pp 423-426 (2023)
Druh dokumentu: article
ISSN: 0370-8179
2406-0895
DOI: 10.2298/SARH221206049L
Popis: Introduction/Objective. Celiac disease (CD) is the result of a polygenic predisposition and gluten-containing diet. The aim of this study was to determine the prevalence and clinical forms of CD in siblings of children with verified disease. Methods. The study included 83 siblings, aged 1.5–27 (11.77 ± 6.2) years, of 64 children with CD diagnosed according to ESPGHAN criteria (1990/2012). In addition to a detailed history and clinical examination, serum levels of IgA and antibodies to tissue transglutaminase (AtTG) IgA and IgG classes were determined in all subjects. All with elevated AtTG levels underwent multiple duodenal enterobiopsy. The diagnosis of CD was confirmed by the finding of characteristic histological changes. Results. The diagnosis of CB was made in 13 of 83 subjects (15.67%). Nine of them had an asymptomatic form of the disease, while in the others the disease was clinically manifested – in three the form was classical, in one it was accompanied by severe malnutrition (-26.80%), and in one the manifestation was nonclassical (only short stature). Except for sideropenia and hypoferritinemia in four patients, of which two with hemoglobin below the reference value, standard laboratory findings were within normal limits. Conclusion. Our research shows that the prevalence of CD in siblings of children with verified disease is 15.67%. It is mostly detected in its asymptomatic form. In accordance with this, routine application of serological screening for CD in this population group is necessary for its timely diagnosis and treatment.
Databáze: Directory of Open Access Journals
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